Current Research Projects

Prior Research Projects

Antioxidants and MRI-Defined Vascular Depression

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Apolipoprotein-E Allele and Cognitive Impairment in the Elderly

Tupler LA, Krishnan KR, Greenberg DL, Marcovina SM, Payne ME, MacFall JR, Charles HC, Doraiswamy PM: Predicting memory decline in normal elderly: Genetics, MRI, and cognitive reserve. Neurobiol Aging 2006; 28(11):1644-1656

Barboriak DP, Doraiswamy PM, Krishnan KR, Vidyarthi S, Sylvester J, Charles HC: Hippocampal Sulcal Cavities on MRI: Relationship to Age and Apolipoprotein E Genotype. Neurology 54.11 (2000): 2150-3

Krishnan KR, Tupler LA, Ritchie JC, Jr., McDonald WM, Knight DL, Nemeroff CB, Carroll BJ: Apolipoprotein E-epsilon 4 frequency in geriatric depression. Biol Psychiatry 1996; 40(1):69-71

Bipolar Disorder in Late Life

Doty TJ, Payne ME, Steffens DC, Beyer JL, Krishnan KR, Labar KS: Age-dependent reduction of amygdala volume in bipolar disorder. Psychiatry Res 2008; 163(1): 84-94

Jones LD, Payne ME, Messer DF, Beyer JL, MacFall JR, Krishnan KR, Taylor WD: Temporal lobe volume in bipolar disorder: Relationship with diagnosis and antipsychotic medication use. J Affect Disord 2009; 114(1-3): 50-7

Beyer JL, Kuchibhatla M, Payne ME, Moo-Young M, Cassidy F, Macfall J, Krishnan KR: Hippocampal volume measurement in older adults with bipolar disorder. Am J Geriatr Psychiatry 2004; 12(6):613-20

Beyer JL, Kuchibhatla M, Payne ME, Moo-Young M, Cassidy F, MacFall JR, Krishnan KR: Caudate volume measurement in older adults with bipolar disorder. Int J Geriatr Psychiatry 2004; 19(2):109-14

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Biomedical Informatics Research Network (BIRN) Project

Qiu A, Taylor WD, Zhao Z, MacFall JR, Miller MI, Key CR, Payne ME, Steffens DC, Krishnan KR: APOE related hippocampal shape alteration in geriatric depression. Neuroimage 2009; 44(3): 620-6

MacFall JR, Taylor WD, Rex DE, Pieper S, Payne ME, McQuoid DR, Steffens DC, Kikinis R, Toga AW, Krishnan KR: Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN). Neuropsychopharmacology 2006; 31(7): 1500-1507

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Geriatric Depression: Prognostic Factors

Taylor WD, Hsu E, Krishnan KR, MacFall JR: Diffusion tensor imaging: background, potential, and utility in psychiatric research. Biological psychiatry 2004; 55(3):201-207

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Late-Life Depression (Including Neurobiology of Cognitive Outcomes of Depression in the Elderly and Conte Center for the Neuroscience of Depression)

Greenberg DL, Payne ME, MacFall JR, Steffens DC, Krishnan KR: Hippocampal volumes and depression subtypes. Psychiatry Res 2008; 163(2): 126-32

Kim KW, MacFall JR, Payne ME: Classification of White Matter Lesions on Magnetic Resonance Imaging in Elderly Persons. Biol Psychiatry 2008; 64(4): 273-80

Payne ME, Anderson JJ, Steffens DC: Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders. Nutrition Research 2008; 23(5): 285-92

Taylor WD, Zuchner S, McQuoid DR, Payne ME, MacFall JR, Steffens DC, Speer MC, Krishnan KR: The Brain-Derived Neurotrophic Factor VAL66MET Polymorphism and Cerebral White Matter Hyperintensities in Late-Life Depression. Biol Psychiatry 2008; 58(12):1017-1023

Pan CC, McQuoid DR, Taylor WD, Payne ME, Ashley-Koch A, Steffens DC: Association analysis of the COMT/MTHFR genes and geriatric depression: An MRI study of the putamen. Int J Geriatr Psychiatry 2009; 24(8): 847-55

Trone RJ, Weaver KG, Steffens DC, Payne ME: Glycemic index and glycemic load are not associated with brain lesions in the elderly. J Nutr Health Aging 2009; 13(2): 117-20

DeBellis MD, Voorhees EV, Hooper SR, Gibler N, Nelson L, Hege SG, Payne ME, MacFall JR: Diffusion Tensor Measures of the Corpus Callosum in Adolescents With Adolescent Onset Alcohol Use Disorders. Alcoholism: Clinical and Experimental Research 2008; 32(3):395-404

Greenberg DL, Messer DF, Payne ME, Macfall JR, Provenzale JM, Steffens DC, Krishnan KR: Aging, gender, and the elderly adult brain: An examination of analytical strategies. Neurobiol Aging 2008: 29(2):290-302

Potter GG, Blackwell AD, McQuoid DR, Payne ME, Steffens DC, Sahakian BJ, Welsh-Bohmer KA, Krishnan KR: Prefrontal White Matter Lesions and Prefrontal Task Impersistence in Depressed and Nondepressed Elders. Neuropsychopharmacology 2007; 32(10):2135-2142

Steffens DC, Potter GG, McQuoid DR, Macfall JR, Payne ME, Burke JR: Longitudinal Magnetic Resonance Imaging Vascular Changes, Apolipoprotein E Genotype, and Development of Dementia in the Neurocognitive Outcomes of Depression in the Elderly Study. Am J Geriatr Psychiatry 2007; 15(10):839-849

Steffens DC, Taylor WD, McQuoid DR, Krishnan KR: Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression. Int J Geriatr Psychiatry 2007

Taylor WD, Macfall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM: Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms. Psychol Med 2007; 37(12):1763-1773

Taylor WD, Zuchner S, Payne ME, Messer DF, Doty TJ, Macfall JR: The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. Psychiatry Res 2007; 155(2):173-177

Taylor WD, MacFall JR, Gerig G, Krishnan, KR: Structural integrity of the uncinate fasciculus in geriatric depression: Relationship with age of onset. Neuropsychiatric Disease and Treatment 2007; 3(5):669-674

Tupler LA, Krishnan KR, Greenberg DL, Marcovina SM, Payne ME, Macfall JR, Charles HC, Doraiswamy PM: Predicting memory decline in normal elderly: Genetics, MRI, and cognitive reserve. Neurobiol Aging 2007; 28(11):1644-1656

Bae JN, Macfall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD: Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex White Matter Alterations in Late-Life Depression. Biol Psychiatry 2006; 60(12):1356-1363

Chen PS, McQuoid DR, Payne ME, Steffens DC:. White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging study. Int Psychogeriatr 2006; 18(3):445-456

Greenberg DL, Payne ME, Macfall JR, Provenzale JM, Steffens DC, Krishnan RR: Differences in brain volumes among males and female hormone-therapy users and nonusers. Psychiatry Res 2006; 147(2-3):127-134

Hannestad J, Taylor WD, McQuoid DR, Payne ME, Krishnan KR, Steffens DC: White matter lesion volumes and caudate volumes in late-life depression. Int J Geriatr Psychiatry 2006; 21(12):1193-1198

Payne ME, Haines PS, Chambless LE, Anderson JJ, Steffens DC: Food group intake and brain lesions in late-life vascular depression. Int Psychogeriatr 2006; 19(2):295-305

Payne ME, Hybels CF, Bales CW, Steffens DC: Vascular Nutritional Correlates of Late-Life Depression. Am J Geriatr Psychiatry 2006; 14(9):787-795

Steffens DC, Pieper CF, Bosworth HB, MacFall JR, Provenzale JM, Payne ME, Carroll BJ, George LK, Krishnan KR: Biological and social predictors of long-term geriatric depression outcome. Int Psychogeriatr 2005; 17(1):41-56

Taylor WD, MacFall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM, Krishnan KR: Greater MRI lesion volumes in elderly depressed subjects than in control subjects. Psychiatry Res 2005; 139(1):1-7

Taylor WD, Steffens DC, Payne ME, MacFall JR, Marchuk DA, Svenson IK, Krishnan KR: Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry 2005; 62(5):537-544

Krishnan KR, Taylor WD, McQuoid DR, MacFall JR, Payne ME, Provenzale JM, Steffens DC: Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression. Biol Psychiatry 2004; 55(4):390-7

Taylor WD, McQuoid DR, Steffens DC, Krishnan KR: Is there a definition of remission in late-life depression that predicts later relapse? Neuropsychopharmacology 2004; 29(12):2272-7

Taylor WD, Hsu E, Krishnan KR, MacFall JR: Diffusion tensor imaging: background, potential, and utility in psychiatric research. Biol Psychiatry 2004; 55(3):201-207

Taylor WD, MacFall JR, Payne ME, McQuoid DR, Provenzale JM, Steffens DC, Krishnan KR: Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry 2004; 161(7):1293-6

Lee SH, Payne ME, Steffens DC, McQuoid DR, Lai TJ, Provenzale JM, Krishnan KR: Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression. Biol Psychiatry 2003; 54(5):529-33

Levy RM, Steffens DC, McQuoid DR, Provenzale JM, MacFall JR, Krishnan KR: MRI lesion severity and mortality in geriatric depression. Am J Geriatr Psychiatry 2003; 11(6):678-82

Steffens DC, Taylor WD, Krishnan KR: Progression of subcortical ischemic disease from vascular depression to vascular dementia. Am J Psychiatry 2003; 160(10):1751-6

Steffens DC, Trost WT, Payne ME, Hybels CF, MacFall JR: Apolipoprotein E genotype and subcortical vascular lesions in older depressed patients and control subjects. Biol Psychiatry 2003; 54(7):674-81

Taylor WD, Steffens DC, McQuoid DR, Payne ME, Lee SH, Lai TJ, Krishnan KR: Smaller orbital frontal cortex volumes associated with functional disability in depressed elders. Biol Psychiatry 2003; 53(2):144-9

Taylor WD, Steffens DC, MacFall JR, McQuoid DR, Payne ME, Provenzale JM, Krishnan KR: White matter hyperintensity progression and late-life depression outcomes. Arch Gen Psychiatry 2003; 60(11):1090-6

Taylor WD, MacFall JR, Steffens DC, Payne ME, Provenzale JM, Krishnan KR: Localization of age-associated white matter hyperintensities in late-life depression. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27(3):539-44

Taylor WD, MacFall JR, Provenzale JM, Payne ME, McQuoid DR, Steffens DC, Krishnan KR: Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors. AJR Am J Roentgenol 2003; 181(2):571-6

Hsieh MH, McQuoid DR, Levy RM, Payne ME, MacFall JR, Steffens DC: Hippocampal volume and antidepressant response in geriatric depression. Int J Geriatr Psychiatry 2002; 17(6):519-25

Kim DM, Xanthakos SA, Tupler LA, Barboriak DP, Charles HC, MacFall JR: MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex. Psychiatry Res 2002; 114(3):149-161

Kim do H, Payne ME, Levy RM, MacFall JR, Steffens DC: APOE genotype and hippocampal volume change in geriatric depression. Biol Psychiatry 2002; 51(5):426-9

Payne ME, Fetzer DL, MacFall JR, Provenzale JM, Byrum CE, Krishnan KR: Development of a semi-automated method for quantification of MRI gray and white matter lesions in geriatric subjects. Psychiatry Res 2002; 115(1-2):63-77

Steffens DC, Payne ME, Greenberg DL, Byrum CE, Welsh-Bohmer KA, Wagner HR, MacFall JR: Hippocampal volume and incident dementia in geriatric depression. Am J Geriatr Psychiatry 2002; 10(1):62-71

Steffens DC, Bosworth HB, Provenzale JM, MacFall JR: Subcortical white matter lesions and functional impairment in geriatric depression. Depress Anxiety 2002; 15(1):23-2

MacFall JR, Payne ME, Provenzale JE, Krishnan KR: Medial orbital frontal lesions in late-onset depression. Biol Psychiatry 2001; 49(9):803-6

Taylor WD, Payne ME, Krishnan KR, Wagner HR, Provenzale JM, Steffens DC, MacFall JR: Evidence of white matter tract disruption in MRI hyperintensities. Biol Psychiatry 2001; 50(3):179-83

Lai T, Payne ME, Byrum CE, Steffens DC, Krishnan KR: Reduction of orbital frontal cortex volume in geriatric depression. Biol Psychiatry 2000; 48(10):971-5

Steffens DC, MacFall JR, Payne ME, Welsh-Bohmer KA, Krishnan KR: Grey-matter lesions and dementia. Lancet 2000; 356(9242):1686-7

Steffens DC, Byrum CE, McQuoid DR, Greenberg DL, Payne ME, Blitchington TF, MacFall JR, Krishnan KR: Hippocampal volume in geriatric depression. Biol Psychiatry 2000; 48(4):301-9

Byrum CE, Ahearn EP, Krishnan KR: A neuroanatomic model for depression. Prog Neuropsychopharmacol Biol Psychiatry 1999; 23(2):175-193

Krishnan KR, Hays JC, George LK, Blazer DG: Six-month outcomes for MRI-related vascular depression. Depress Anxiety 1998; 8(4):142-146

Steffens DC, Krishnan KR: Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions. Biol Psychiatry 1998; 43(10):705-712

Krishnan KR, Hays JC, Blazer DG: MRI-defined vascular depression. Am J Psychiatry 1997; 154(4):497-501

Steffens DC, McDonald WM, Tupler LA, Boyko OB, Krishnan KR: Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects. Psychiatry Res 1996; 68(1):55-61

Byrum CE, MacFall JR, Charles HC, Chitilla VR, Boyko OB, Upchurch L: Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method. Psychiatry Res 1996; 67(3):215-234

MacFall JR, Byrum CE, Parashos I, Early B, Charles HC, Chittilla V, Boyko OB, Upchurch L, Krishnan KR: Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods. Psychiatry Res 1994; 55(3):167-77

Krishnan KR, Boyko OB, McDonald WM, Charles CH, MacFall JR, Tupler LA, Upchurch LW: Magnetic-Resonance Morphometry: Image-analysis methodology developement for affective disorder. Depression 1 (1993): 159-171

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Neuroimaging in Neurofibromatosis

Greenwood RS, Tupler LA, Whitt JK, Buu A, Dombeck CB, Harp AG, Payne ME, Eastwood JD, Krishnan KR, MacFall JR: Brain morphometry, T2-weighted hyperintensities, and IQ in children with neurofibromatosis type 1. Archives of neurology 2005; 62(12):1904-1908

Neurological Effects of Marijuana

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