 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
Updated: copyright, 2004 |
Apolipoprotein-E Allele and Cognitive Impairments
| Funded by: | National Institutes of Health | |
| Co-Investigators: | P. Murali Doraiswamy, MD | |
| H. Cecil Charles, PhD | ||
| Larry A. Tupler, PhD |
In recent years, apolipoprotein E (ApoE) E4 has been established as a significant risk factor for Alzheimer's disease (AD). The relationship, however, between ApoE isoform status and age-associated memory impairment (AAMI), which often progresses to AD, is unknown. We are studying the neuroanatomical and neuropsychological implications of ApoE E4 in elderly individuals with AAMI, compared with age- and sex-matched controls. In particular, we are examining hippocampal and whole-brain volume in ApoE E4 individuals compared with ApoE E3 individuals. We are also examining memory functions (delayed free recall, cued recall, recognition, and multiple-trial learning) as they relate to ApoE isoform status and neuroanatomical measures.