Lesion studies have made an important contribution to the analysis of circuits involved in a variety of cognitive, motor and sensory functions. These studies, combined with imaging and postmortem studies, can enhance our understanding of brain mechanisms underlying psychiatric disorder. Conte Center utilizes these approaches to study unipolar depression.

The primary hypothesis underlying the Center is that lesions in critical regions of the brain which disrupt the brain circuits lead to structural, functional, cognitive and biochemical changes that predispose one to the development of depression. The current Center proposes to test the structural, biochemical and functional consequences of the circuit disruption.

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