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Updated: copyright, 2004 |
Neuroimaging in Neurofibromatosis 1
| Funded by: | National Institutes of Health |
| Principal Investigator: | Robert S. Greenwood, MD |
| Duke PI: | James R. MacFall, PhD |
| Co-Investigators: | James D. Eastwood, MD |
| Larry A. Tupler, PhD |
We are conducting a follow-up to our 1996 cross-sectional study published in Neuroreport (7:1941-1944)† in which we examined gray- and white-matter volumes in children with neurofibromatosis type 1 (NF1). In that paper, we observed significantly larger brain volumes in NF1 children compared with controls, particularly in white matter. Performance on Judgment of Line Orientation and the Developmental Test of Visual-Motor Integration was also positively correlated with right hemisphere gray matter volume in NF1 children.
Our present grant examines longitudinal brain changes in NF1 children, compared with genetically related, non-NF1 controls. NF1 and control pairs are being examined over a 5-year period, assessed twice with MRI and three times with neuropsychological testing.
†Said, S. M., Yeh, T. L., Greenwood, R. S., Whitt, J. K., Tupler, L. A., and Krishnan, K. R. (1996). "MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis." Neuroreport 7:1941-4.